This year 2.25 million Americans will get married—and a million will  get divorced. Could birth control be to blame for some of these  breakups? Recent research suggests that the contraceptive pill—which  prevents women from ovulating by fooling their body into believing it is  pregnant—could affect which types of men women desire. Going on or off  the pill during a relationship, therefore, may tempt a woman away from  her man.
It’s all about scent. Hidden in a man’s smell are clues about his  major histocompatibility complex (MHC) genes, which play an important  role in immune system surveillance. Studies suggest that females prefer  the scent of males whose MHC genes differ from their own, a preference  that has probably evolved because it helps offspring survive: couples  with different MHC genes are less likely to be related to each other  than couples with similar genes are, and their children are born with  more varied MHC profiles and thus more robust immune systems.
A study published in August in the 
Proceedings of the Royal Society B,  however, suggests that women on the pill undergo a shift in preference  toward men who share similar MHC genes. The female subjects were more  likely to rate these genetically similar men’s scents (via a T-shirt the  men had worn for two nights) as pleasant and desirable after they went  on the pill as compared with before. Although no one knows why the pill  affects attraction, some scientists believe that pregnancy—or in this  case, the hormonal changes that mimic pregnancy—draws women toward  nurturing relatives.
Women who start or stop taking the pill, then, may be in for some relationship problems. A study published last year in 
Psychological Science  found that women paired with MHC-similar men are less sexually  satisfied and more likely to cheat on their partners than women paired  with MHC-dissimilar men. So a woman on the pill, for example, might be  more likely to start dating a MHC-similar man, but he could ultimately  leave her less sexually satisfied. Then if she goes off the pill during  the relationship, the accompanying hormonal changes will draw her even  more strongly toward more MHC-dissimilar men. These immune genes may  have a “powerful effect in terms of how well relationships are  cemented,” says University of Liverpool psychologist Craig Roberts,  co-author of the August paper.
Note: This article was originally published with the title, "A Tough Pill to Swallow".